Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in Yersinia pestis
CE Chandler, EM Harberts… - Proceedings of the …, 2020 - National Acad Sciences
… A number of virulence factors have been shown to suppress … of LPS is known to induce
proinflammatory responses via the … Here, we describe a powerful analytical method called Gene …
proinflammatory responses via the … Here, we describe a powerful analytical method called Gene …
Contributions of Yersinia pestis outer membrane protein Ail to plague pathogenesis
AM Kolodziejek, CJ Hovde… - Current Opinion in …, 2022 - ingentaconnect.com
… Ail is shown to be an essential virulence factor with multiple … factors: YadA and the O-chain
in lipopolysaccharide (LPS). … polymorphonuclear leukocyte response during bubonic plague. …
in lipopolysaccharide (LPS). … polymorphonuclear leukocyte response during bubonic plague. …
Induction of protective antiplague immune responses by self-adjuvanting bionanoparticles derived from engineered Yersinia pestis
… package multiple virulence factors, including virulence effectors … To overcome this deficiency,
we constructed a balanced-… groups in lipid A units in LPS on the bacterial membrane and …
we constructed a balanced-… groups in lipid A units in LPS on the bacterial membrane and …
Protection Elicited by Attenuated Live Yersinia pestis Vaccine Strains against Lethal Infection with Virulent Y. pestis
CK Cote, SS Biryukov, CP Klimko, JL Shoe, M Hunter… - Vaccines, 2021 - mdpi.com
… V antigens could overcome F1-V induced immunity [4]. … the genes for all potential virulence
factors and vaccine antigens, … coli lpxL (hexa-acylated lipid A) LPS variant [3]. The strain was …
factors and vaccine antigens, … coli lpxL (hexa-acylated lipid A) LPS variant [3]. The strain was …
Yersinia pestis Plasminogen Activator
… pestis overcomes the innate immunity of its host thanks to many pathogenicity factors, … pestis
or the LPS of E. coli producing Pla negatively impacts Pla activity [40]. Furthermore, gradual …
or the LPS of E. coli producing Pla negatively impacts Pla activity [40]. Furthermore, gradual …
[HTML][HTML] Yersinia pestis escapes entrapment in thrombi by targeting platelet function
SG Palace, O Vitseva, MK Proulx, JE Freedman… - Journal of Thrombosis …, 2020 - Elsevier
… overcome platelet thrombotic functions in the vasculature. Here, we show that the
bacteremia‐causing pathogen Y pestis uses specific virulence factors … of lipopolysaccharide (LPS) …
bacteremia‐causing pathogen Y pestis uses specific virulence factors … of lipopolysaccharide (LPS) …
Yersinia pestis Δail Mutants Are Not Susceptible to Human Complement Bactericidal Activity in the Flea
AM Kolodziejek, SW Bearden, S Maes… - Applied and …, 2023 - Am Soc Microbiol
… resistance in humans and is a critical virulence factor of Y. … Mammalian blood complement
exerts strong selective pressure … LPS was a critical step in the transition to the highly virulent Y. …
exerts strong selective pressure … LPS was a critical step in the transition to the highly virulent Y. …
Genome Scale Analysis Reveals IscR Directly and Indirectly Regulates Virulence Factor Genes in Pathogenic Yersinia
…, P Alvarez, G Saarunya, N Tanner, A Zoubedi, Y Wei… - MBio, 2021 - Am Soc Microbiol
… The plague agent Yersinia pestis is closely related to Y. … Interestingly, we found in this study
that a number of Yersinia LPS … in iron homeostasis, virulence, stress response, and other …
that a number of Yersinia LPS … in iron homeostasis, virulence, stress response, and other …
Platelets—Disarmed guardians in the fight against the plague
A Assinger - Journal of Thrombosis and Haemostasis, 2020 - jthjournal.org
… However, Y pestis lipopolysaccharide manages to evade … Virulence factors of Yersinia pestis
are overcome by a strong … current knowledge on Y pestis‐derived virulence factors and add …
are overcome by a strong … current knowledge on Y pestis‐derived virulence factors and add …
Redundant and cooperative roles for Yersinia pestis Yop effectors in the inhibition of human neutrophil exocytic responses revealed by gain-of-function approach
AR Pulsifer, A Vashishta, SA Reeves… - Infection and …, 2020 - Am Soc Microbiol
… , is more limited and requires stronger stimulation to promote granule … pestis encodes a
variety of virulence factors to evade … of neutrophils with lipopolysaccharide (LPS) results in TAK1-…
variety of virulence factors to evade … of neutrophils with lipopolysaccharide (LPS) results in TAK1-…